Kozik has worked with Nirvana, Pearl Jam, Soundgarden, Stone Temple Pilots, the Red Hot Chili Peppers, Melvins, The Offspring, Butthole Surfers, and Helmet. Kozik used to run Man's Ruin Records, a media outlet and record label, and has published several books including Man's Ruin: Posters and Art by Frank Kozik and Desperate Measures Empty Pleasures. Kozik has been described as "one of the rock world's top poster artists", and interviewed in Rolling Stone. Kozik created Smorkin' Labbit and is the Creative Director of Kidrobot. Kozik has been a force in the designer toy movement with many of his works produced in that form.